abstract：:This study shows that chronic, long-hospitalized schizophrenics perform (tested by the Famous Events Questionnaire) at a higher level on remote memory than they do on word list recall. A post hoc, matched-tasks check suggested that this finding was not due to differences in the discriminating power of the tasks. Relat...

journal_title：Biological psychiatry

authors： Calev A,Berlin H,Lerer B

更新日期：1987-01-01 00:00:00

abstract：:[3H]imipramine binding to platelets was measured in 17 drug-free panic disorder patients and 14 healthy controls. No difference in Bmax or Kd values was found between the two groups. Patients with a past history of major melancholic depression or severe agoraphobia had similar binding parameters as panic disorder pati...

journal_title：Biological psychiatry

authors： Uhde TW,Berrettini WH,Roy-Byrne PP,Boulenger JP,Post RM

更新日期：1987-01-01 00:00:00

abstract：:Sixty patients with affective illness were examined by computed tomography (CT) and compared to 60 age- and sex-matched controls. Using three different methods of measurement, no differences in ventricular brain ratio (VBR) between patients and controls could be detected. However, linear ventricular values of the fron...

journal_title：Biological psychiatry

authors： Schlegel S,Kretzschmar K

更新日期：1987-01-01 00:00:00

abstract：:Natural lithium (Li) salts, including those used routinely in manic depressive illness, consist of two stable nonradioactive isotopes: lithium-7 (Li-7) (92.6%) and lithium-6 (Li-6) (7.4%). Female rats (3 months old) were treated with either Li-7 chloride or Li-6 chloride or were untreated prior to and during gestation...

journal_title：Biological psychiatry

authors： Sechzer JA,Lieberman KW,Alexander GJ,Weidman D,Stokes PE

更新日期：1986-11-01 00:00:00

abstract：:We examined the association between post-dexamethasone suppression test (DST) serum cortisol and body weight, self-report of weight loss during the episode, and measured weight loss during the first week of admission in a series of 245 depressed inpatients. Data on measured weight loss between two successive admission...

journal_title：Biological psychiatry

authors： Pfohl B,Coryell W,Stangl D,Zimmerman M

更新日期：1986-08-01 00:00:00

abstract：:The effect of individual plasma proteins on the binding of 3H-imipramine (3H-IMI) was investigated, using rat cerebral membranes as the binding site source. Addition of alpha-1-acid glycoprotein (aAGLP) to an incubation medium containing 4 nm 3H-IMI resulted in a concentration-dependent inhibition of 3H-IMI binding, w...

journal_title：Biological psychiatry

authors： Barkai AI,Baron M,Kowalik S,Cooper TB

更新日期：1986-08-01 00:00:00

abstract：:The present study was undertaken in order to further explore the relationship between monoamine levels and hypothalamic-pituitary-adrenocortical (HYPAC) functioning and suicidal behavior in depressed patients. One hundred and thirty-two depressed inpatients participated in the NIMH Collaborative Study on the Psychobio...

journal_title：Biological psychiatry

authors： Secunda SK,Cross CK,Koslow S,Katz MM,Kocsis J,Maas JW,Landis H

更新日期：1986-07-01 00:00:00

abstract：:Previous studies suggest that catecholaminergic overactivity and structural brain damage may contribute to the pathogenesis of tardive dyskinesia (TD). Although dopaminergic (DA) mechanisms, specifically postsynaptic receptor supersensitivity, have been extensively studied, equally plausible noradrenergic (NE) changes...

journal_title：Biological psychiatry

authors： Kaufmann CA,Jeste DV,Shelton RC,Linnoila M,Kafka MS,Wyatt RJ

更新日期：1986-07-01 00:00:00

abstract：:It has been suggested that the signs and symptoms of the ethanol withdrawal syndrome may be due to the increased production of an "inverse agonist" that binds to the central benzodiazepine (BZ) recognition site in the brain. Ro 15-1788 (a potent antagonist at the central BZ recognition site), diazepam, and Ro 15-1788 ...

journal_title：Biological psychiatry

authors： Adinoff B,Majchrowicz E,Martin PR,Linnoila M

更新日期：1986-06-01 00:00:00

abstract：:Somatostatin is a tetradecapeptide that is assuming increasing importance as a regulator of central nervous system activity. Originally identified as the hypothalamic growth hormone release-inhibiting factor, somatostatin has subsequently been shown to be extensively and selectively distributed throughout the central ...

journal_title：Biological psychiatry

authors： Rubinow DR

更新日期：1986-04-01 00:00:00

abstract：:The effects of naltrexone on both mood and cognition were examined in overweight male subjects. Subjects were randomly prescribed, in a double-blind fashion, either placebo or naltrexone for 8 weeks. The results of the study showed that a chronic administration of a high dose of naltrexone (300 mg/day) does not signif...

journal_title：Biological psychiatry

authors： Hatsukami DK,Mitchell JE,Morley JE,Morgan SF,Levine AS

更新日期：1986-03-01 00:00:00

abstract：:It has previously been demonstrated that direct opiate infusion into nucleus accumbens elicits psychomotor activation in rats. In the present study, the effects of chronic treatment with five different neuroleptics on this behavioral response were investigated. All neuroleptics tested (haloperidol, sulpiride, flupenti...

journal_title：Biological psychiatry

authors： Stinus L,Nadaud D,Jauregui J,Kelley AE

更新日期：1986-01-01 00:00:00

abstract：:Two lines of rats that were selectively bred to vary in their sensitivity to the anticholinesterase DFP exhibited different degrees of behavioral depression after injection of the muscarinic agonist arecoline (2 mg/kg). The line of rats with increased behavioral depression after arecoline (the Flinders sensitive or S-...

journal_title：Biological psychiatry

authors： Overstreet DH

更新日期：1986-01-01 00:00:00

abstract：:In a sample of 13 endogenous depressive inpatients, REM (rapid eye movement) latency (recorded over 4 consecutive nights after 2 habituation nights) and contingent negative variation amplitude showed significant relationship, suggesting that both parameters may depend on the same mechanisms, possibly cholinergic. ...

journal_title：Biological psychiatry

authors： Ansseau M,Machowski R,Franck G,Timsit-Berthier M

更新日期：1985-12-01 00:00:00

abstract：:Because available evidence suggests that alterations in the serotonergic as well as dopaminergic tones underlie hallucinatory activity, we decided to investigate whether serotonin and dopamine pathways are modified in alcoholics with a history of hallucinosis. Brain serotonin has been shown to depend on the plasma rat...

journal_title：Biological psychiatry

authors： Branchey L,Branchey M,Worner TM,Zucker D,Shaw S,Lieber CS

更新日期：1985-11-01 00:00:00

abstract：:Determinations of albumin and immunoglobulin G (IgG) were performed in paired cerebrospinal fluid (CSF) and serum samples from 24 subjects with schizophrenia. These determinations allowed calculation of two indices, one that is an indicator of integrity of the blood-brain barrier and the other a measure of selective I...

journal_title：Biological psychiatry

authors： Kirch DG,Kaufmann CA,Papadopoulos NM,Martin B,Weinberger DR

更新日期：1985-10-01 00:00:00

abstract：:We compared the EEG-monitored sleep of 8 women with anorexia nervosa and 16 normal weight women with bulimia to that of 14 normal women. The patients with anorexia nervosa spent less time asleep and spent less of their sleep time in Stage 1. The sleep of the normal weight patients with bulimia was remarkably similar t...

journal_title：Biological psychiatry

authors： Walsh BT,Goetz R,Roose SP,Fingeroth S,Glassman AH

更新日期：1985-09-01 00:00:00

abstract：:In an investigation of biological indicators of stress in normal humans, undergraduate psychology students were differentiated on trait anxiety and assessed under baseline, preexam (stress), and postexam conditions. Assessment at each condition involved drawing 20 ml of blood, followed by self-reporting for selected q...

journal_title：Biological psychiatry

authors： Davis DD,Dunlop SR,Shea P,Brittain H,Hendrie HC

更新日期：1985-08-01 00:00:00

abstract：:Injection of ferric chloride (FC) into the left amygdala of rats produced limbic seizures that lasted at least 3 weeks. In addition, FC-injected animals demonstrated motor impairment, decreased protesting vocalizations, and spontaneous stereotypies during a behavioral examination. An increase in apomorphine-induced st...

journal_title：Biological psychiatry

authors： Csernansky JG,Csernansky CA,Bonnet KA,Hollister LE

更新日期：1985-07-01 00:00:00

abstract：:Drugs with antidepressant properties in patients with severe depression also have various behavioral and neurochemical effects in animals. This has given rise to numerous animal models that have been suggested to be valid for research into the neurobiology of depression and the neurochemical mechanisms of the antidepr...

journal_title：Biological psychiatry

authors： Jesberger JA,Richardson JS

更新日期：1985-07-01 00:00:00

abstract：:Animal studies indicate that seizures can be produced reliably with a fraction of the electrical energy now required by currently available electroconvulsive therapy (ECT) instruments. This may result in further reduction of the side effects of ECT. The stimulus energy does not necessarily correspond to the energy dep...

journal_title：Biological psychiatry

authors： Hyrman V,Palmer LH,Cernik J,Jetelina J

更新日期：1985-06-01 00:00:00

abstract：:The specific binding to platelet membranes (Bmax) of 3H-clonidine, an alpha-2 agonist, and 3H-yohimbine, an alpha-2 antagonist, was measured in nine drug-free male schizophrenic patients and repeated after 2 weeks of chlorpromazine (CPZ) treatment. Patients with a lower pretreatment Bmax for 3H-clonidine showed a sign...

journal_title：Biological psychiatry

authors： Rosen J,Silk KR,Rice HE,Smith CB

更新日期：1985-05-01 00:00:00

abstract：:Seventeen drug-free patients with Alzheimer's disease (AD) and 15 normal elderly controls, of which 13 age- and sex-matched pairs were included, participated in a study of red blood cell (RBC) and plasma choline. Mean values for RBC choline, plasma choline, and the ratio of RBC/plasma choline did not differ between th...

journal_title：Biological psychiatry

authors： Greenwald BS,Edasery J,Mohs RC,Shah N,Trigos GG,Davis KL

更新日期：1985-04-01 00:00:00

abstract：:Our previous studies have shown that in psychotics, the plasma serine level is abnormally high and that plasma serine hydroxymethyltransferase (which cleaves serine to glycine) activity is abnormally low as compared with that in nonpsychotic subjects. In this study, psychotic and nonpsychotic subjects ingested a large...

journal_title：Biological psychiatry

authors： Wilcox J,Waziri R,Sherman A,Mott J

更新日期：1985-01-01 00:00:00

abstract：:With a computerized data base, a data retrieval system, and a computer program using the actuarial method of life-table analysis, we compared survival rates in different subgroups of patients with dementia of the Alzheimer type (DAT; n = 199). Men (n = 71) had a shorter duration of survival than women (n = 128), with ...

journal_title：Biological psychiatry

authors： Barclay LL,Zemcov A,Blass JP,McDowell FH

更新日期：1985-01-01 00:00:00

abstract：:It has been generally accepted that increased thyroid function facilitates treatment response in depression. Recent data show that response to several antidepressant treatments, particularly lithium and carbamazepine, are associated with decreased thyroid hormone levels. An alternative hypothesis that decreased thyroi...

journal_title：Biological psychiatry

authors： Joffe RT,Roy-Byrne PP,Udhe TW,Post RM

更新日期：1984-12-01 00:00:00

abstract：:Several studies have reported prolonged neural transmission times on auditory brainstem responses (ABRs) measured in autistic children, a finding which implicates CNS dysfunction at the level of the brainstem in autistic conditions. This study measured ABRs in 25 children and adults with pervasive developmental disord...

journal_title：Biological psychiatry

authors： Rumsey JM,Grimes AM,Pikus AM,Duara R,Ismond DR

更新日期：1984-10-01 00:00:00

abstract：:There has been a continuing interest in the possible role of the trace amine tryptamine in the etiology of neuropsychiatric disorders. We have therefore examined cerebrospinal fluid (CSF) levels of indole-3-acetic acid (IAA), the major metabolite of tryptamine, in a large group of normals and in several patient popula...

journal_title：Biological psychiatry

authors： Anderson GM,Gerner RH,Cohen DJ,Fairbanks L

更新日期：1984-10-01 00:00:00

abstract：:There is indirect evidence that smoking induces higher enzymatic activity which accelerates the metabolism of many drugs. This influence is inferred from the frequency and magnitude of drug side effects. We could demonstrate that smokers need higher doses of neuroleptic drugs than nonsmokers. ...

journal_title：Biological psychiatry

authors： Vinarová E,Vinar O,Kalvach Z

更新日期：1984-08-01 00:00:00

abstract：:Opponent processes have long been known to be a basic building block of neural circuits. This article describes properties of opponent processes in which phasic cues and tonic arousal are gated by slowly accumulating chemical transmitters. These opponent processes are called gated dipoles. Gated dipole circuits exhibi...

journal_title：Biological psychiatry

authors： Grossberg S

更新日期：1984-07-01 00:00:00

abstract：:A 37-year-old female with Capgras syndrome was assessed on psychometric and neuropsychological measures. Significant neuropsychological deficits suggesting a frontal-temporal cerebral dysfunction were observed. The results demonstrate that the Capgras delusion involves more than an inability to recognize faces, althou...

journal_title：Biological psychiatry

authors： Morrison RL,Tarter RE

更新日期：1984-07-01 00:00:00

abstract：:Quantitative and qualitative measures of brain morphology were derived through CT scans using computer-assisted methodology in patients with schizophrenia or schizo-affective psychosis and headache controls. Schizophrenics had significantly higher density of white matter, together with greater right vs. left asymmetry...

journal_title：Biological psychiatry

authors： Largen JW Jr,Smith RC,Calderon M,Baumgartner R,Lu RB,Schoolar JC,Ravichandran GK

更新日期：1984-07-01 00:00:00

abstract：:The behavioral effects of a 2 mg/kg iv bolus infusion of naloxone were compared with a placebo infusion using a double-blind design in a small group of inpatient depressives (n = 6) and normals (n = 8). Naloxone produced consistent and significant worsening in the rated signs and subjective symptoms of depression in t...

journal_title：Biological psychiatry

authors： Cohen MR,Cohen RM,Pickar D,Sunderland T,Mueller EA 3rd,Murphy DL

更新日期：1984-06-01 00:00:00

abstract：:Extensive work in the field has indicated a state-dependent hyperactivity of the hypothalamic-pituitary-adrenocortical (HYPAC) functions and unresponsiveness to dexamethasone suppression in at least 50% of patients suffering from endogenous depression. In this study, elderly outpatients, 60-85 years of age, suffering ...

journal_title：Biological psychiatry

authors： Georgotas A,Stokes PE,Krakowski M,Fanelli C,Cooper T

更新日期：1984-05-01 00:00:00

abstract：:This paper reviews and correlates three separate recent findings that implicate the one-carbon cycle in neuropsychiatric disease: (i) the demonstration by kinetic studies that the Vmax of methionine adenosine transferase (MAT) is reduced in some schizophrenics and depressives and is increased in some manics, and that ...

journal_title：Biological psychiatry

authors： Smythies JR

更新日期：1984-05-01 00:00:00

abstract：:A group of 759 patients with final DSM-I and -II diagnoses of schizophrenia was identified among a cohort of 1494 adults who were hospitalized between 1965 and 1972. Admission EEG recordings were done in each patient during waking, activation procedures, drowsiness, and sleep. All cases were reclassified according to ...

journal_title：Biological psychiatry

authors： Small JG,Milstein V,Sharpley PH,Klapper M,Small IF

更新日期：1984-04-01 00:00:00

abstract：:Six female outpatients with Alzheimer's disease (AD) along with four female controls of a similar age range were analyzed for sister chromatid exchangers (SCEs), cell cycle kinetics, and sensitivity to mutagens, in lymphocyte cultures. The mean level of SCEs for the AD patients was 11.40 SCEs/metaphase, while that for...

journal_title：Biological psychiatry

authors： Fischman HK,Reisberg B,Albu P,Ferris SH,Rainer JD

更新日期：1984-03-01 00:00:00

abstract：:Phencyclidine induced dose-related alterations in the pattern of spontaneous aggressive behavior in pairs of rats, in which only one animal of each pair was drug-treated. At the lowest dose tested (0.25 mg/kg, sc), phencyclidine produced attacks by the drug-treated animal and a corresponding increase in submissive beh...

journal_title：Biological psychiatry

authors： Russell JW,Greenberg BD,Segal DS

更新日期：1984-02-01 00:00:00

abstract：:Using computed tomography, lateral ventricular size was determined in 45 schizophrenic and 22 affective disorder patients, and was found in both patient groups to be greater than that of 62 similarly aged headache controls. While drug-free, the 15 schizophrenics with ventricles 1 standard deviation greater than the ag...

journal_title：Biological psychiatry

authors： Luchins DJ,Lewine RR,Meltzer HY

更新日期：1984-01-01 00:00:00

abstract：:Sixty psychiatrically depressed patients (female = 39, male = 21), classified as psychotic or neurotic, were neuropsychologically assessed on an expanded Halstead-Reitan battery before antidepressant medication. Extant normative data from a large control group (N = 142) were employed for comparative purposes. Statisti...

journal_title：Biological psychiatry

authors： Fromm D,Schopflocher D

更新日期：1984-01-01 00:00:00